How should I take Paxil (Paroxetine)? Take Paxil exactly as prescribed by your doctor. Follow all directions on your prescription label. Your doctor may occasionally change your dose. Do not take this medicine in larger or smaller amounts or for longer than recommended. Do not crush, chew, or break an extended-release Paxil tablet. Swallow the tablet whole. Store at room temperature away from moisture, heat, and light.