How to take Lisinopril. Take lisinopril exactly as prescribed by your doctor. Follow all directions on your prescription label. Drink plenty of water each day while you are taking this medicine. Lisinopril can be taken with or without food. Measure liquid medicine with the dosing syringe provided, or with a special dose-measuring spoon or medicine cup. If you do not have a dose-measuring device, ask your pharmacist for one.