What is Repatha (Evolocumab)? Evolocumab is used to help lower “bad” cholesterol (LDL) in the blood. For people who have a certain inherited condition that causes high levels of LDL (heterozygous familial hypercholesterolemia) or who have a blockage in the heart blood vessels, it is used along with a proper diet and a “statin” drug in the highest amount they can take.