How to take Keppra (Levetiracetam)? Take Keppra exactly as prescribed by your doctor. Follow all directions on your prescription label. Keppra is usually taken once every 12 to 24 hours. Take the medicine at the same time each day. You may take this medicine with or without food. Measure liquid medicine with the dosing syringe provided, or with a special dose-measuring spoon or medicine cup. Do not crush, chew, or break an extended-release tablet. Swallow the tablet whole.