What is Invokana (Canagliflozin)? Invokana (Canagliflozin) is an oral diabetes medicine that helps control blood sugar levels. Canagliflozin works by helping the kidneys get rid of glucose from your bloodstream. Invokana is used together with diet and exercise to improve blood sugar control in adults with type 2 diabetes. Invokana is not for treating type 1 diabetes.