How to take Depakote (Divalproex sodium). Take Depakote exactly as prescribed by your doctor. Drink plenty of water while you are taking this medication. Your dose may need to be changed if you do not get enough fluids each day. You may open the Depakote sprinkle capsule and sprinkle the medicine into a spoonful of pudding or applesauce to make swallowing easier. Swallow this mixture right away. Do not crush, chew, break, or open a delayed-release or extended-release tablet or capsule. Swallow it whole.