How to take Coreg (Carvedilol). Read the Patient Information Leaflet if available from your pharmacist before you start taking carvedilol and each time you get a refill. If you have any questions, ask your doctor or pharmacist. Take this medication by mouth with food as directed by your doctor, usually twice daily. Take this medication regularly to get the most benefit from it. To help you remember, take it at the same times each day.