Clindamycin interactions. Some products that may interact with this drug include: macrolide antibiotics (e.g., clarithromycin, erythromycin), kaolin-pectin. Although most antibiotics are unlikely to affect hormonal birth control such as pills, patch, or ring, a few antibiotics (such as rifampin, rifabutin) can decrease their effectiveness. This could result in pregnancy. If you use hormonal birth control, ask your doctor or pharmacist for more details.