Clindamycin serious side effects. Stop using clindamycin and call your doctor at once if you have any of these serious side effects:

  • diarrhea that is watery or bloody
  • jaundice (yellowing of the skin or eyes)
  • urinating less than usual or not at all
  • fever, chills, body aches, flu symptoms, sores in your mouth and throat
  • easy bruising, unusual bleeding (nose, mouth, or rectum), purple or red pinpoint spots under your skin
  • severe skin reaction – fever, sore throat, swelling in your face or tongue, burning in your eyes, skin pain, followed by a red or purple skin rash that spreads (especially in the face or upper body) and causes blistering and peeling