How to take Clindamycin. Take the capsule with a full glass of water to keep it from irritating your throat. Measure the oral liquid with the dosing syringe provided, or with a special dose-measuring spoon or medicine cup. Clindamycin is sometimes given as an injection into a muscle, or injected into a vein through an IV. You may be shown how to use injections at home. Do not self-inject this medicine if you do not understand how to give the injection and properly dispose of used needles, IV tubing, and other items used to inject the medicine.