How to take Bydureon. Bydureon is injected under the skin. You may be shown how to use injections at home. Do not give yourself this medicine if you do not understand how to use the injection and properly dispose of used needles and syringes. Bydureon is usually injected once every 7 days. Bydureon can be used with or without food and given at any time of the day. Follow your doctor’s instructions. You may change your weekly dosing day, but do not inject on your new dosing day if it has been less than 3 days since your last dose.