How to take Brilinta (Ticagrelor). Take Brilinta exactly as prescribed by your doctor. Brilinta should be taken together with aspirin. Follow your doctor’s instructions about how much aspirin you should take. Do not take more aspirin than your doctor has prescribed. Taking too much aspirin can make Brilinta less effective. This medicine can be taken with or without food. Take the medicine at the same time each day.