How to take Biaxin (Clarithromycin). You may take Biaxin tablets and oral suspension (liquid) with or without food. Clarithromycin extended-release tablets (Biaxin XL) should be taken with food. Do not crush, chew, or break an extended-release tablet. Swallow it whole. Shake the oral suspension (liquid) well just before you measure a dose. Measure liquid medicine with the dosing syringe provided, or with a special dose-measuring spoon or medicine cup.